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產(chǎn)品名稱

Recombinant Human ICAM-3-Fc Chimera (carrier-free) from BIOLEGEND

產(chǎn)品貨號

771508

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

500 μg

產(chǎn)品品牌

BIOLEGEND

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Recombinant Human ICAM-3-Fc Chimera (carrier-free)
Description	Intercellular Adhesion Molecule-3 (ICAM-3, CD50) is a highly glycosylated protein that belongs to immunoglobulin superfamily.? It has five extracellular Ig-like domains and binds the leukocyte integrins LFA-1 (CD11a/CD18) and αdβ2.? ICAM-3 is broadly expressed on leukocytes, endothelial cells, and Langerhans cells.? ICAM-3 is an adhesion molecule with signal transducing functions involved in immune responses.? LFA-1/ICAM-3 interactions between APC and resting T cells provide costimulatory signals that are important for initiating immune responses. ?LFA-1/ICAM-3 interactions can also exert inhibitory effects on proliferating T cells.? ICAM-3 induces intracellular Ca2+ mobilization and undergoes phosphorylation on tyrosine residue leading to association with the tyrosine phosphatase, CD45. ?Soluble forms of ICAM-3 have been found to be elevated in the circulation of patients with autoimmune disorders. ?Alternative splicing results in multiple transcript variants encoding different isoforms. Diseases associated with ICAM3 include Actinic Prurigo and Trichosporonosis.
Size	500 μg
Concentration	n/a
Applications	BA
Other Names	Intercellular adhesion molecule 3, CD50
Gene, Accession, CAS #	Gene ID: 3385
Catalog #	771508
Price
Order / More Info	Recombinant Human ICAM-3-Fc Chimera (carrier-free) from BIOLEGEND
Product Specific References	n/a
產(chǎn)品資料

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