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        產(chǎn)品名稱 Recombinant Mouse Wnt3a from BIOLEGEND
        產(chǎn)品貨號(hào) 772302
        產(chǎn)品價(jià)格 現(xiàn)貨詢價(jià),電話:010-67529703
        產(chǎn)品規(guī)格 10 μg
        產(chǎn)品品牌 BIOLEGEND
        產(chǎn)品概述
        產(chǎn)品詳情
        Edit&nbsp
        Product NameRecombinant Mouse Wnt3a
        DescriptionWnt-3a belongs to Wnt family of proteins that consist of structurally related genes encoding highly conserved cysteine rich secreted glycoproteins. Wnt family proteins have been implicated in oncogenesis and in multiple developmental processes including regulation of cell fate and patterning during embryogenesis. Wnts are ligand for seven-pass transmembrane receptors of the frizzled family. Wnts bind Frizzled receptors and forms complex with low-density lipoprotein receptor-related protein (LRP5 or LRP6) which results in the stabilization of intracellular beta-catenin levels. Intracellular accumulation of beta-catenin increases translocation of the protein into the nucleus, where it binds to TCF/LEF transcription factors to promote expression of Wnt target genes. Lack of Wnt signaling disrupts transcriptional activation of tumor suppressor genes, and has been shown to result in neoplastic transformation, oncogenesis, and human degenerative disease. Wnt-3a is a highly conserved lipid-modified, secreted hydrophobic glycoprotein with conserved 24 cysteine residues that is essential for cell signaling. Wnt-3a is required for normal embryonic mesoderm development and formation of caudal somites. It is also required for normal morphogenesis of the developing neural tube. Wnt-3a mediates self-renewal of the stem cells at the bottom on intestinal crypts.
        Size10 μg
        Concentrationn/a
        ApplicationsBA
        Other Nameswingless-type MMTV integration site family, member 3A, Wnt-3a, vt
        Gene, Accession, CAS #Gene ID: 22416
        Catalog #772302
        Price
        Order / More InfoRecombinant Mouse Wnt3a from BIOLEGEND
        Product Specific Referencesn/a
        產(chǎn)品資料
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