| 產(chǎn)品詳情 |
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| Product Name | Recombinant Human IGF-BP7 (carrier-free) |
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| Description | IGF-BP7 belongs to the insulin-like growth factor-binding protein family. It shares 20 - 25% identity with other members of the family. IGF-BP7 contains the common IGFBP motif (GCGCCXXC) at the N-terminal, in a region containing the cysteine-rich domain that is conserved among the IGFBPs. It also possesses a C-terminal Ig-like domain. IGFBPs bind IGF peptides with high affinity and regulate the biological activities of IGFs. IGF-BP7 binds to IGF-I, IGF-II, and insulin (with very low affinity). IGF-BP7 also binds to IGF-1R and blocks its activation by insulin-like growth factors as well. Results from extended incubations with IGF-BP7 indicate that there is an activation of the translational repressor 4E-binding protein 1 (4E-BP1), enhanced sensitivity to apoptosis in IGF1R-positive cells, and subsequent inhibition to protein synthesis, cell growth, and survival in the treated cells. IGF-BP7 is abundantly expressed by normal tissues; nevertheless, no or very low expression is detected in advanced stages of many cancers. The expression of IGF-BP7 correlates with favorable prognosis in colon cancer patients. IGF-BP7 may have a?potential tumor suppressor role in the treatment of different types of cancer, including cervical cancer, osteosarcoma, prostate cancer, breast cancer, lung cancer, melanoma, thyroid cancer, and hepatocellular carcinomas. |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Insulin-like growth factor binding protein 7, Tumor derived adhesion factor (TAF/AGM), FSTL2, IBP-7, IGFBP-7v, IGFBP7, IGFBP-7, IBP7, IGFBP related protein 1 (IGFBPRP1), Meningioma associated cDNA 25 (MAC25), Prostacyclin-stimulating factor (PSF), RAMSVPS |
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| Gene, Accession, CAS # | Gene ID: 3490 |
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| Catalog # | 555106 |
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| Price | |
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| Order / More Info | Recombinant Human IGF-BP7 (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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