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產(chǎn)品名稱

LBP, Human Antibody from HYCULT BIOTECH

產(chǎn)品貨號(hào)

HM2044

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	LBP, Human
Clone	1C7
Host Species	Mouse
Reactive Species	human
Isotype	IgG1
Format	unconjugated
Size	100 μg
Concentration	100 μg/ml
Applications	functional studies, immunoassay, IP
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	The monoclonal antibody 1C7 reacts highly specific with human natural and recombinant LBP. Crossreactions with LBP of other species are not observed. The antibody binds poorly to LBP-LPS complexes: it interacts with the LPS binding site. LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000 fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria.
Immunogen	n/a
Other Names	n/a
Gene, Accession #	n/a
Catalog #	HM2044
Price
Order / More Info	LBP, Human Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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