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產(chǎn)品名稱

Recombinant Human CCL2 (MCP-1) (carrier-free) from BIOLEGEND

產(chǎn)品貨號

571404

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

25 μg

產(chǎn)品品牌

BIOLEGEND

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Recombinant Human CCL2 (MCP-1) (carrier-free)
Description	CCL2, also known as?MCP-1, is a member of the CC ? chemokine family. It is widely expressed in endothelial cells, smooth muscle cells and monocytes in response to several atherogenic stimulants such as CD40 ligand, platelet derived growth factor (PDGF), interleukin-1β (IL-1β) and oxidized low density lipoprotein. Several recent in vivo studies have disclosed critical roles of MCP1 in atherosclerosis. In addition, MCP-1 has been implicated in monocytic infiltration of tissues during several inflammatory diseases, and has been implicated in macrophage-mediated tumor growth suppression in mice. CCL2 has been shown to have direct effects on tumor cells in an autocrine and paracrine fashion in multiple cancers, including breast, lung, cervix, ovary, sarcoma, and prostate. In addition, MCP-1 plays a key role in the regulation of MMPs during transmigration.MCP-1/CCl2 has been described as a new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy. Kidney epithelial cells, including glomerular podocytes and tubular cells make MCP-1 in response to high glucose and advanced glycation end products. MCP-1 promotes inflammation and progressive injury in diabetic kidneys. The importance of MCP-1 in the early development of diabetic nephropathy has been determined in animal models incorporating genetically deficient mice or therapeutic blockade of MCP-1 receptor (CCR2).
Size	25 μg
Concentration	n/a
Applications	BA
Other Names	Monocyte chemoattractant protein-1, MCAF, JE, SCYA2, HC-11, P6, SMC-CF, CCL2, MCP1
Gene, Accession, CAS #	Gene ID: 6347
Catalog #	571404
Price
Order / More Info	Recombinant Human CCL2 (MCP-1) (carrier-free) from BIOLEGEND
Product Specific References	n/a
產(chǎn)品資料

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