| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Product Name | Recombinant Human CCL7 (MCP-3) (carrier-free) |
|---|
| Description | CCL7, also known as MCP-3, was initially purified from cytokine-stimulated human osteosarcoma cell line (MG-63) conditioned medium. CCL7 has high similarity with CCL2/MCP-1 (71%), CCL8/MCP-2 (58%), and CCL13/MCP-4 (59%) at the amino acid level. Chemokines play a key role in inflammation and, in the initial phase, CXC chemokines chemoattract polymorphonuclear leukocytes (PMNs). The next step in the inflammatory processes is directed in part by CC chemokines, including the monocyte chemoattractant proteins (CCL2, CCL7, CCL8, and CCL13) that chemoattract additional leukocytes subsets. It has been reported that MMPs regulate chemokine bioactivity, increasing or decreasing their chemoattractant property; MMP-8 and MMP-9 modulate CXC chemokines, and MMP-2 truncates the N-terminal of CCL7, eliminating the first four amino acids producing CCL7 (5-76 residues), which leads to a loss of activity. The truncated CCL7 binds to its receptor, but it does not induce signaling transduction. MCPs are truncated by different MMPs to create potent antagonists and induce decreases in inflammation. For example, MMP-13 cleaves CCL2 and CCL7 and generates potent receptor antagonists. Also, CCL7 and CCL2 play an important role in the pathogenesis of systemic sclerosis (SSc). It has been described that they are overexpressed in SSc and activate collagen production in dermal fibroblasts. In addition, CCL7 and CCL21 are highly expressed in gastric cancer and are associated with lymph node metastasis and poor prognosis. |
|---|
| Size | 100 μg |
|---|
| Concentration | n/a |
|---|
| Applications | BA |
|---|
| Other Names | Monocyte chemotactic protein3 (MCP-3, MCP3); Small inducible cytokine subfamily A, member 7 (SCYA7) |
|---|
| Gene, Accession, CAS # | Gene ID: 6354 |
|---|
| Catalog # | 585706 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Human CCL7 (MCP-3) (carrier-free) from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
色综合色色色,久久精品视频在线播放,成人无码高清免费视频
|
一极毛片,冲田杏梨av在线播放,超碰人人操在线
|
成人在线黄色视频,国产无码午夜,台湾三级网
|
操大奶熟女,美女一区二区三区在线观看,靠逼操逼操逼网站
|
国产精品久久久久久亚洲影视,欧美性大战久久,双飞高潮一直喷水视频
|
亚洲AV成人无码久久精品巨臀,大香蕉色综合,A亚洲免费电影
国产精品影音先锋,台湾精品一区二区,久久久久久黄
亚洲色网视频,乱伦91视频,日韩精品极品视频在线观看免费
|
五月丁香性爱,揉我胸啊嗯出水了,夜夜夜夜猛噜噜噜噜噜噜燥
|
精产国品一区二区区别,韩国三级中文字幕,黄片操比
|
丁香五月天综合网,ai换脸明星被吸乳视频,日韩无码激情片
|
蜜桃媒AV成人片免费看,国产精品.www,亚洲AV无码精品久久一区二区
|
|