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產(chǎn)品名稱

Recombinant Human PCSK9 (carrier-free) from BIOLEGEND

產(chǎn)品貨號

592506

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

BIOLEGEND

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Recombinant Human PCSK9 (carrier-free)
Description	Protein convertase subtilisin/kexin 9 (PCSK9) possesses a signal peptide ( aa 1-30), a prosegment (PRO) (aa 31-152), a catalytic domain (aa 153-407), a hinge region (aa 408-452), and a C-terminal Cys-His-rich domain (CHRD) (aa 453-692).? This protein is primarily synthesized and secreted by hepatocytes.? Besides liver, it is also expressed in the small intestine, kidney, and brain, and it is present in plasma.? Upon translocation to the endoplasmic reticulum, the prosegment of PCSK9 is autocatalytically cleaved at the VFAQ152QSIP site and secreted as a stable, enzymatically inactive, non-covalent complex.? Elevated low density lipoprotein-cholesterol (LDLc) level is a major risk factor for cardiovascular disease and atherosclerosis.? LDLc is cleared from circulation by the LDL receptor (LDLR); PCSK9 is a regulator of LDLc levels through the binding of LDLR, subsequently leading to the degradation of LDLR.? Therefore, it is biologically plausible that drugs inhibiting PCSK9 would lower heart attacks and other diseases caused by increased cholesterol.? PCSK9 also binds to other LDLR family members such as very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER), and apolipoprotein receptor 2 (LRP8/APOER2), which lead to their degradation in the intracellular acidic compartments.? Like the LDLR, gene expression of PCSK9 is positively regulated by SREBP-2, a transcription factor that is activated in response to cellular cholesterol depletion.
Size	100 μg
Concentration	n/a
Applications	BA
Other Names	Neural Apoptosis Regulated Convertase 1 (NARC1), Proprotein convertase PC9, subtilisin/kexin-like protease PC9
Gene, Accession, CAS #	Gene ID: 255738
Catalog #	592506
Price
Order / More Info	Recombinant Human PCSK9 (carrier-free) from BIOLEGEND
Product Specific References	n/a
產(chǎn)品資料

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