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產(chǎn)品名稱

EGLN3, 1-239aa, Human, His tag, E.coli from ATGen

產(chǎn)品貨號

ATGP1609

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

100ug, 20ug, 4ug

產(chǎn)品品牌

ATGen

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	EGLN3, 1-239aa, Human, His tag, E.coli
Description	Purity: 0.25 mg/ml (determined by Bradford assay) Format: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 50% glycerol, 0.3M NaCl, 5mM DTT, 2mM EDTA. EGLN3, a member of the EGLN family of prolyl hydroxylases, has been shown to catalyze hydroxylation of the alpha subunit of hypoxia-inducible factor-alpha, which targets hypoxia-inducible factor-alpha for ubiquitination by a ubiquitin ligase complex containing the von Hippel-Lindau (VHL) tumor suppressor. EGLN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM2 in hypoxia, limiting glycolysis. under normoxia, hydroxylates and regulates the stability of ADRB2. Recombinant human EGLN3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Size	100ug, 20ug, 4ug
Concentration	n/a
Applications	SDS-PAGE
Other Names	Egl nine homolog 3, HIFPH3, PHD3
Gene, Accession, CAS #	NP 071356
Catalog #	ATGP1609
Price
Order / More Info	EGLN3, 1-239aa, Human, His tag, E.coli from ATGen
Product Specific References	n/a
產(chǎn)品資料

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