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產(chǎn)品名稱

C3aR, Mouse Antibody from HYCULT BIOTECH

產(chǎn)品貨號(hào)

HM1123

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	C3aR, Mouse
Clone	14D4
Host Species	Rat
Reactive Species	mouse
Isotype	IgG2a
Format	unconjugated
Size	100 μg
Concentration	100 μg/ml
Applications	frozen sections, FC
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	The monoclonal antibody 14D4 reacts with mouse C3aR, which is a member of the rhodopsin superfamily of 7-transmembrane G protein-coupled receptors, with a molecular weight of approximately 54 kDa. Expression of C3aR has been demonstrated on a wide variety of immune cells, including monocytes, macrophages, dendritic cells, neutrophils, basophils, eosinophils, mast cells, T lymphocytes and B lymphocytes. In addition, C3aR is found on cells of the central nervous system, lungs and kidney. In the course of complement activation C3aR functions as the cell surface receptor for C3a, which is the C-terminal 77 amino acid cleavage product of C3. C3a, possesses both anaphylatoxic and immunoregulatory properties, such as smooth muscle contraction, histamine release from mast cells, and enhanced vascular permeability. In addition, C3a induces respiratory burst in neutrophils and has chemotactic properties for eosinophils and mast cells. Moreover, C3a causes release of key cytokines from multiple cell types, including IL-1β, TNF-α, IL-6 and IL-8. A role for C3aR has been implicated in several murine disease models. It was shown that C3aR inhibition reduces neurodegeneration in experimental lupus, whereas in a murine model of allergic airway disease, deletion of the C3a receptor protects against the changes in lung physiology seen after allergen challenge. Finally, it was shown that deletion of C3aR is protective in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.
Immunogen	RBL-2H3 transfectants expressing mouse C3aR
Other Names	n/a
Gene, Accession #	n/a
Catalog #	HM1123
Price
Order / More Info	C3aR, Mouse Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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