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        產(chǎn)品名稱 human CD45 Antibody from BOSTER BIO
        產(chǎn)品貨號(hào) FC00555-PerCP
        產(chǎn)品價(jià)格 現(xiàn)貨詢價(jià),電話:010-67529703
        產(chǎn)品規(guī)格 25 Tests, 100 Tests, 200 Tests
        產(chǎn)品品牌 BOSTER BIO
        產(chǎn)品概述
        產(chǎn)品詳情
        Edit&nbsp
        Antigenic Specificityhuman CD45
        CloneF10-89-4
        Host SpeciesMouse
        Reactive Specieshuman
        IsotypeIgG2a,k
        FormatPerCP conjugate
        Size25 Tests, 100 Tests, 200 Tests
        Concentration0.5-1mg/ml, actual concentration varies by lot.
        ApplicationsFlow Cytometry
        Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
        DescriptionMouse Monoclonal Anti-human CD45 PerCP Conjugated, designed for Flow Cytometry and validated by Flow Cytometry using Human cells. CD45(Cluster of Differentiation 45), also known as PTPRC, LCA or CD45R, is an enzyme that, in humans, is encoded by the PTPRC gene.CD45 is a member of the protein tyrosine phosphatase(PTP) family. CD45 is a major high molecular mass leukocyte cell surface molecule which is also an integral membrane protein tyrosine phosphatase.The cytogenetic location of CD45 is 1q31.3-q32.1. CD45 is especially a prototype for transmembrane protein-tyrosine phosphatase(PTP). Targeted disruption of the CD45 gene leads to enhanced cytokine and interferon receptor-mediated activation of JAKs and STAT proteins. In vitro, CD45 directly dephosphorylates and binds to JAKs. Functionally, CD45 negatively regulates interleukin-3-mediated cellular proliferation, erythropoietin-dependent hematopoiesis, and antiviral responses in vitro and in vivo. CD45 has been best studied in T cells, where it determines T cell receptor signaling thresholds. CD45 is moved into or out of the immunological synapse(IS) membrane microdomain depending on the relative influence of interaction with the extracellular galectin lattice or the intracellular actin cytoskeleton. Galectin interaction can be finetuned by varying usage of the heavily Oglycosylated spliced regions and sialylation of Nlinked carbohydrates.
        ImmunogenHuman T lymphocytes
        Other NamesReceptor-type tyrosine-protein phosphatase C;3.1.3.48;Leukocyte common antigen;L-CA;T200;CD45;PTPRC;CD45;
        Gene, Accession #PTPRC, UniProt: P08575
        Catalog #FC00555-PerCP
        Price
        Order / More Infohuman CD45 Antibody from BOSTER BIO
        Product Specific Referencesn/a
        產(chǎn)品資料
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