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產(chǎn)品名稱

human CD45 Antibody from BOSTER BIO

產(chǎn)品貨號

FC00555

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100μg, 500μg

產(chǎn)品品牌

BOSTER BIO

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	human CD45
Clone	F10-89-4
Host Species	Mouse
Reactive Species	human
Isotype	IgG2a,k
Format	Protein A purified
Size	100μg, 500μg
Concentration	0.5-1mg/ml, actual concentration varies by lot.
Applications	Flow Cytometry
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Mouse Monoclonal Anti-human CD45 Unconjugated, designed for Flow Cytometry and validated by Flow Cytometry using Human cells. CD45(Cluster of Differentiation 45), also known as PTPRC, LCA or CD45R, is an enzyme that, in humans, is encoded by the PTPRC gene.CD45 is a member of the protein tyrosine phosphatase(PTP) family. CD45 is a major high molecular mass leukocyte cell surface molecule which is also an integral membrane protein tyrosine phosphatase.The cytogenetic location of CD45 is 1q31.3-q32.1. CD45 is especially a prototype for transmembrane protein-tyrosine phosphatase(PTP). Targeted disruption of the CD45 gene leads to enhanced cytokine and interferon receptor-mediated activation of JAKs and STAT proteins. In vitro, CD45 directly dephosphorylates and binds to JAKs. Functionally, CD45 negatively regulates interleukin-3-mediated cellular proliferation, erythropoietin-dependent hematopoiesis, and antiviral responses in vitro and in vivo. CD45 has been best studied in T cells, where it determines T cell receptor signaling thresholds. CD45 is moved into or out of the immunological synapse(IS) membrane microdomain depending on the relative influence of interaction with the extracellular galectin lattice or the intracellular actin cytoskeleton. Galectin interaction can be finetuned by varying usage of the heavily Oglycosylated spliced regions and sialylation of Nlinked carbohydrates.
Immunogen	Human T lymphocytes
Other Names	Receptor-type tyrosine-protein phosphatase C;3.1.3.48;Leukocyte common antigen;L-CA;T200;CD45;PTPRC;CD45;
Gene, Accession #	PTPRC, UniProt: P08575
Catalog #	FC00555
Price
Order / More Info	human CD45 Antibody from BOSTER BIO
Product Specific References	n/a
產(chǎn)品資料

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