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產(chǎn)品名稱

HdmX/MDM4 Antibody from BIOVISION, INC.

產(chǎn)品貨號

3762-100

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

100 μl

產(chǎn)品品牌

BIOVISION, INC.

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	HdmX/MDM4
Clone	polyclonal
Host Species	Rabbit
Reactive Species	human
Isotype	n/a
Format	affinity purified
Size	100 μl
Concentration	n/a
Applications	Western blot, Immunoprecipitation
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	HdmX/MDM4 Antibody. The MDM2 protein is the primary regulator of p53 protein stability. MDMX is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 via distinct associations with MDM2. The gene that encodes MDMX (also designated MDM4) is a target for amplification in malignant gliomas. ARF interacts with MDMX to sequester MDMX within the nucleolus. This sequestration of MDMX by ARF results in an increase in p53 transactivation. In addition, expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation. Like MDM2, MDMX also binds p73 and stabilizes the level of p73. Therefore, in striking contrast to p53, the half-life of p73 is increased by binding to MDM2.
Immunogen	Synthetic peptide of human HmdX/MDM4
Other Names	HdmX, MdmX, MDM4, homolog of mouse double minute 4 protein
Gene, Accession #	Gene ID: 4194, Accession: O15151
Catalog #	3762-100
Price
Order / More Info	HdmX/MDM4 Antibody from BIOVISION, INC.
Product Specific References	n/a
產(chǎn)品資料

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