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| Antigenic Specificity | Smad4 |
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| Clone | RM277 |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | IgG |
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| Format | affinity purified |
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| Size | 50 μl |
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| Concentration | n/a |
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| Applications | WB, IHC |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Monoclonal antibody to detect Smad4 in human samples. Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad), have been implicated as downstream effectors of TGFβ/BMP signaling. Smad1, Smad5, and Smad8 are effectors of BMP2 and BMP4 function while Smad2 and Smad3 are involved in TGF-β and activin-mediated growth modulation. Smad4 has been shown to mediate all of the above activities throμgh interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFβ signaling by interfering with TGFβ-mediated phosphorylation of other Smad family members. |
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| Immunogen | A peptide corresponding to the C-terminus of human Smad4 |
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| Other Names | SMAD family member, Mothers against decapentaplegic homolog, MAD homolog, Mothers against DPP homolog, SMAD4 |
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| Gene, Accession # | Gene ID: 4089, Accession: Q9BYG6 |
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| Catalog # | A1605-50 |
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| Price | |
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| Order / More Info | Smad4 Antibody from BIOVISION, INC. |
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| Product Specific References | n/a |
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