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產(chǎn)品名稱

Recombinant Human ICAM-2 (carrier-free) from BIOLEGEND

產(chǎn)品貨號(hào)

768504

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

25 μg

產(chǎn)品品牌

BIOLEGEND

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Recombinant Human ICAM-2 (carrier-free)
Description	ICAM-2 is a type I transmembrane glycoprotein containing two extracellular Ig superfamily domains, a hydrophobic transmembrane region, and a short cytoplasmic domain, constitutively expressed on various cell types including T and B lymphocytes, macrophages, NK cells, monocytes, dendritic cells, neutrophils, endothelial cells, platelets, and CD34+ hematopoietic progenitor cells. ?Primarily localized to apical surface near intercellular junctions, ICAM-2 mediates cell binding to integrins like LFA-1 (αLβ2, CD11a/Cd18) and MAC-1 (αMβ2, CD11b/CD18) with strong implications in angiogenesis, inflammation, and cell survival. Specifically, it plays an essential role in lymphocyte adhesion, recruitment, trafficking, recirculation, and extravasation. ?ICAM-2 associates with ERM (ezrin/radixin/moesin) proteins to activate PI3K/Akt pathway and subsequently inhibit apoptosis in leukocytes and fibroblasts, while promoting capillary tube formation and junction maturation in endothelial cells via triggering of small GTPase Rac1activation. ?ICAM-2 is the only member of all ICAMs that maps to chromosome 17q23-25, a segment known for genomic instability and high aberration in cancers. ?ICAM-2 is refractory to pro-inflammatory cytokines such as IL-1, TNF-α, and IFN-γ, the very proteins that strongly upregulate ICAM-1 expression on endothelial cells both in vitro and in vivo.
Size	25 μg
Concentration	n/a
Applications	BA
Other Names	Intercellular adhesion molecule 2, ICAM2
Gene, Accession, CAS #	Gene ID: 3384
Catalog #	768504
Price
Order / More Info	Recombinant Human ICAM-2 (carrier-free) from BIOLEGEND
Product Specific References	n/a
產(chǎn)品資料

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