| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Product Name | Recombinant Human ICAM-2 (carrier-free) |
|---|
| Description | ICAM-2 is a type I transmembrane glycoprotein containing two extracellular Ig superfamily domains, a hydrophobic transmembrane region, and a short cytoplasmic domain, constitutively expressed on various cell types including T and B lymphocytes, macrophages, NK cells, monocytes, dendritic cells, neutrophils, endothelial cells, platelets, and CD34+ hematopoietic progenitor cells. ?Primarily localized to apical surface near intercellular junctions, ICAM-2 mediates cell binding to integrins like LFA-1 (αLβ2, CD11a/Cd18) and MAC-1 (αMβ2, CD11b/CD18) with strong implications in angiogenesis, inflammation, and cell survival. Specifically, it plays an essential role in lymphocyte adhesion, recruitment, trafficking, recirculation, and extravasation. ?ICAM-2 associates with ERM (ezrin/radixin/moesin) proteins to activate PI3K/Akt pathway and subsequently inhibit apoptosis in leukocytes and fibroblasts, while promoting capillary tube formation and junction maturation in endothelial cells via triggering of small GTPase Rac1activation. ?ICAM-2 is the only member of all ICAMs that maps to chromosome 17q23-25, a segment known for genomic instability and high aberration in cancers. ?ICAM-2 is refractory to pro-inflammatory cytokines such as IL-1, TNF-α, and IFN-γ, the very proteins that strongly upregulate ICAM-1 expression on endothelial cells both in vitro and in vivo. |
|---|
| Size | 500 μg |
|---|
| Concentration | n/a |
|---|
| Applications | BA |
|---|
| Other Names | Intercellular adhesion molecule 2, ICAM2 |
|---|
| Gene, Accession, CAS # | Gene ID: 3384 |
|---|
| Catalog # | 768508 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Human ICAM-2 (carrier-free) from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
欧美日韩一区精品,97国产福利,Ts视频在线观看一区二区三区
|
翔田千里毛片,北条麻妃肉色开裆丝袜,欧美国产日韩一区二区在线观看
|
91午夜福利视频,女流氓用手揉我的裆部,91乱码少妇在线观看
|
亚洲 图片 小说 欧美 另类,日日夜夜爽爽,日韩日批视频
|
夜夜高潮夜夜操天天操,把护士日出水120分钟视频,无码专区在线
|
麻豆传媒换妻操逼图,永久黄色视频,精品无码人妻一区二区媚黑
|
国产伦精品一区二区三区妓女原神,潘金莲一级淫片aaa观看,精精品人妻一区二区三区
|
韩国毛片无码,伸进她的小内裤疯狂揉摸没声音,成人AV电影网站
|
国产成人毛片,深夜福利二区,男女交性视频无遮挡全过程
|
操女网,女人张开腿给男人桶,免费看中国操逼视频
|
|