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| Product Name | I-BET 151 dihydrochloride |
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| Description | BET bromodomain inhibitor; blocks recruitment of BET to chromatin. Induces apoptosis and G0/G1 cell cycle arrest in MLL-fusion leukemic cell lines in vitro (IC50 values are 15, 26, 120 and 192 nM for NOMO1, MV4;11, MOLM13 and RS4;11 cell lines respectively); reduces BCL2 expression in NOMO1 cells. Improves survival in two rodent models of MLL-fusion leukemia in vivo. Enhances differentiation of human iPSC into megakaryocytes. Purity 98%. MW (observed): 488.37 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydroxy-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one dihydrochloride |
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| Gene, Accession, CAS # | CAS: 1883545-47-8 |
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| Catalog # | 4650/10 |
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| Price | |
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| Order / More Info | I-BET 151 dihydrochloride from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 25807524 |
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