| Description | Potent Smoothened (Smo) receptor antagonist (IC50 = 5 nM). Inhibits the Hedgehog signaling pathway. Inhibits Shh induced Gli luciferase reporter activity in Shh-light 2 cells (IC50 = 5 nM). Antagonizes GSA-10 and SAG -mediated differentiation of the C3H10T1/2 cell line (IC50 values are 69 and 115 nM, respectively). Purity 98%. MW (observed): 379.5 |
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