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產(chǎn)品名稱

C-646 from ARBOR ASSAYS, INC.

產(chǎn)品貨號

P014-5MG

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

5 mg

產(chǎn)品品牌

ARBOR ASSAYS, INC.

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	C-646
Description	A reversible, cell-permeable pyrazolone p300/CBP HAT inhibitor (Ki = 400 nM), which competes with acetyl-CoA for the p300 Lys-CoA binding pocket. Demonstrates 86% inhibition against p300 at 10 nM. Less than 10% inhibition against serotonin N-acetyltransferase, PCAF, GCN5, Rtt109, Sas, and MOZ HATs in a chemical screening assay. Treatment of C3H 10T1/2 mouse fibroblasts at 25 uM results in an inhibitory effect against basal and TSA-inducible acetylation of histones H3 and H4. Shown to inhibit human cell growth in melanoma and non-small cell-lung cancer cell lines at 10 uM with similar or higher potency than peptide-based bisubstrate p300/CBP HAT inhibitor Lys-CoA-Tat at 25 uM.
Size	5 mg
Concentration	n/a
Applications	Activator or Inhibitor
Other Names	p300 HAT inhibitor
Gene, Accession, CAS #	n/a
Catalog #	P014-5MG
Price
Order / More Info	C-646 from ARBOR ASSAYS, INC.
Product Specific References	n/a
產(chǎn)品資料

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