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產(chǎn)品名稱

WM902B Viable Cells (1 x 10^6 cells) from ROCKLAND IMMUNOCHEMICALS INC.

產(chǎn)品貨號

WM902B-01-0001

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

1 mL

產(chǎn)品品牌

ROCKLAND IMMUNOCHEMICALS INC.

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	WM902B Viable Cells (1 x 10^6 cells)
Description	WM902B is a tumorigenic (VGP) primary melanoma cell line with competence for metastasis. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell line also expresses PTEN loss of function including hemizygous deletion and R24L mutation at position 24 in the CDK4 gene. The R24L mutation results in an amino acid substitution at codon 24 in CDK4, from an arginine (R) to Leucine (L). This mutation renders the protein resistant to the inhibitory effects of INK4A function. WM902B cells produce xenograft tumors when injected into immunocompromised mice.
Size	1 mL
Concentration	1x10^6
Applications	The key applications of these cell lines include genetic studies, xenograft production, drug testing, and drug target discovery. These cell line models can be used in various biological assays, and for identifying critical target genes, and cell signaling pathways.
Other Names	Human Melanoma, patient derived tumor, tumor models, skin cancer, xenograft
Gene, Accession, CAS #	n/a
Catalog #	WM902B-01-0001
Price
Order / More Info	WM902B Viable Cells (1 x 10^6 cells) from ROCKLAND IMMUNOCHEMICALS INC.
Product Specific References	n/a
產(chǎn)品資料

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