| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | Siglec-H, Mouse |
|---|
| Clone | 44c |
|---|
| Host Species | Rat |
|---|
| Reactive Species | mouse |
|---|
| Isotype | IgG2b |
|---|
| Format | biotin conjugate |
|---|
| Size | 50 μg |
|---|
| Concentration | 100 μg/ml |
|---|
| Applications | frozen sections, FC |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | The monoclonal antibody 440c reacts with Siglec-H, a cell-surface receptor molecule selectively expressed on murine natural interferon producing cells (IPC), also called mouse plasmacytoid dendritic cells (pDC). Siglec H is unique among Sialic acid-binding Ig-like lectins (Siglecs) proteins because it associates with the adaptor protein DAP12. DAP12 recognize certain viruses and CpG-DNA through TLR9, resulting in secretion of IFN-alpha, IL-12 and proinflammatory chemokines. Together these cytokines and chemokines recruite and activate NK cells and T cells as well as modulating the antigen presenting function of dendritic cells (DC). IPC themselves also function as antigen presenting cells that expand memory T cells and induce Th1 differentiation. Therefore IPC may provide a first line of host defense against viral infections by activating both innate and adaptive responses in vivo. The monoclonal antibody 440c exclusively recognizes mouse Siglec-H in all lymphoid organs under both normal and inflammatory conditions. Siglec-H is normal present in the T cell zone of lymph nodes and spleen. Incubation of IPC with antibody 440c in vitro or administration of antibody 440c in vivo reduces secretion of IFN-alpha in response to CpG DNA without causing IPC depletion. |
|---|
| Immunogen | n/a |
|---|
| Other Names | n/a |
|---|
| Gene, Accession # | n/a |
|---|
| Catalog # | HM1095 |
|---|
| Price | |
|---|
| Order / More Info | Siglec-H, Mouse Antibody from HYCULT BIOTECH |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
在线播放成人网站,黄色1级视频,日逼av网站
|
大雞巴疯狂浓精合集,久久国产精品嫩草影院的使用方法,羽月希奶水无码播放
|
色播综合,美女扒开腿让男人爽视频,四虎久久久
|
无码+麻豆 视频,中文字幕国产精品视频,久久成人精品一区二区
|
舔舔小核,国产高清不卡视频,人妻丝袜
|
老女人爽视频,午夜视频在线观看91,日韩七区
|
日逼无码,啊啊啊好大好爽在线观看,伊人无码在线观看
|
天天搞天天插,天天插AV,囯产精品久久久
|
国产成人精品一区二区色戒,欧美黄色一级录像,红色一级A片
|
九九热精品在线播放,国产又猛又粗,久久人人爽av亚洲精品天堂牛牛
|
|