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產(chǎn)品名稱

Recombinant Mouse Dual specificity mitogen-activated protein kinase kinase 4 (Map2k4) from BIOMATIK

產(chǎn)品貨號(hào)

RPC21643

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100ug

產(chǎn)品品牌

BIOMATIK

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Recombinant Mouse Dual specificity mitogen-activated protein kinase kinase 4 (Map2k4)
Description	Purity > 90% as determined by SDS-PAGE. MW: 60kDa. Full Length of Mature Protein: 2-397a. N-terminal 6xHis-SUMO-tagged. Mus musculus (Mouse). Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 ses to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
Size	100ug
Concentration	n/a
Applications	RUO
Other Names	C-JUN N-terminal kinase kinase 1; JNK kinase 1; JNKK 1JNK-activating kinase 1MAPK/ERK kinase 4; MEK 4SAPK/ERK kinase 1; SEK1
Gene, Accession, CAS #	Map2k4, UniProt: P47809
Catalog #	RPC21643
Price
Order / More Info	Recombinant Mouse Dual specificity mitogen-activated protein kinase kinase 4 (Map2k4) from BIOMATIK
Product Specific References	n/a
產(chǎn)品資料

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