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| Product Name | Go 6976 |
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| Description | Potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM). Discriminates between Ca2+-dependent and -independent isoforms of PKC in vitro; selectively inhibits PKCα and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively). Does not inhibit the activity of PKCδ, -ε, or -ζ (IC50 > 3μM). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC50 values are 5, 30, 130 and 370 nM respectively), PKCμ (PKD1) and the mitotic spindle checkpoint. Purity 98%. MW (observed): 378.43 |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile |
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| Gene, Accession, CAS # | CAS: 136194-77-9 |
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| Catalog # | 2253/1 |
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| Price | |
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| Order / More Info | Go 6976 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 19366805, 21145007, 21930714, 23055494, 24404335, 24748172, 25124035, 25699542, 26245668, 26512957, 30543664 |
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