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產品名稱

Netrin 1/NTN1 Antibody from BOSTER BIO

產品貨號

PA1662

產品價格

現貨詢價，電話：010-67529703

產品規(guī)格

100ug (sample available)

產品品牌

BOSTER BIO

產品概述

產品詳情

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Antigenic Specificity	Netrin 1/NTN1
Clone	polyclonal
Host Species	Rabbit
Reactive Species	human, mouse, rat (predicted: bovine)
Isotype	n/a
Format	immunogen affinity purified
Size	100ug (sample available)
Concentration	500ug/ml.
Applications	WB
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Rabbit IgG polyclonal antibody for Netrin-1(NTN1) detection. Tested with WB in Human;Mouse;Rat. No cross reactivity with other proteins. Netrin-1(NTN1), also known as NTN1L, is a diffusible protein made by floor plate cells. Netrin-1 is found in the floor plate and neuroepithelial cells of the ventral region of the spinal cord, as well as other locations in the nervous system including the somatic mesoderm, pancreas and cardiac muscle. The human NTN1 gene is mapped to chromosome 17p13-p12 by FISH. Netrin-1 can attract spinal commissural axons and repel trochlear axons in vitro. And netrin-1 expression confers a selective advantage for tumor cell survival. The binding of netrin-1 to DCC appears to depend on the presence of a coreceptor or accessory proteins. Adenosine A2b receptor is actually a netrin-1 receptor and induces cAMP accumulation on binding netrin-1, and that netrin-1-dependent outgrowth of dorsal spinal cord axons directly involves A2b. Netrin-1 can promote intestinal tumor development, probably by regulating cell survival. Thus, a netrin-1 receptor or receptors function as conditional tumor suppressors. Expression of Unc5b triggered endothelial cell repulsion in response to netrin-1 in vitro, whereas a truncated Unc5b lacking the intracellular signaling domain failed to induce repulsion.
Immunogen	A synthetic peptide corresponding to a sequence at the N-terminus of human Netrin 1(32-51aa AGQAAQPDPCSDENGHPRRC), identical to the related rat and mouse sequences.
Other Names	Netrin-1;Epididymis tissue protein Li 131P;NTN1;NTN1L;
Gene, Accession #	NTN1, UniProt: O95631
Catalog #	PA1662
Price
Order / More Info	Netrin 1/NTN1 Antibody from BOSTER BIO
Product Specific References	n/a
產品資料

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