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產(chǎn)品名稱

Recombinant Human Protein-arginine deiminase type-4 (PADI4) from BIOMATIK

產(chǎn)品貨號

RPC25925

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

100ug

產(chǎn)品品牌

BIOMATIK

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Recombinant Human Protein-arginine deiminase type-4 (PADI4)
Description	Purity > 85% as determined by SDS-PAGE. MW: 81.1kDa. Full Length: 1-663aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Homo sapiens (Human). Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.
Size	100ug
Concentration	n/a
Applications	RUO
Other Names	HL-60 PAD; Peptidylarginine deiminase IV; Protein-arginine deiminase type IV; PAD4, PADI5, PDI5
Gene, Accession, CAS #	PADI4, UniProt: Q9UM07
Catalog #	RPC25925
Price
Order / More Info	Recombinant Human Protein-arginine deiminase type-4 (PADI4) from BIOMATIK
Product Specific References	n/a
產(chǎn)品資料

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