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產(chǎn)品名稱

WM46 Purified RNA from ROCKLAND IMMUNOCHEMICALS INC.

產(chǎn)品貨號(hào)

WM46-04-0500

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

10 μg

產(chǎn)品品牌

ROCKLAND IMMUNOCHEMICALS INC.

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	WM46 Purified RNA
Description	Total RNA was prepared from cell line WM46. WM46 is a metastatic human melanoma cell line that displays a pigmented fibroblastic morphology. This cell line was established from left chest & abdomen in a 43-year-old female patient with level IV superficial spreading melanoma and a tumor thickness of 1.44. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell line expresses PTEN loss of function including hemizygous deletion, and R24C mutation at position 24 in the CDK4 gene. The R24C mutation results in an amino acid substitution at codon 24 in CDK4, from an arginine (R) to cysteine (C). This mutation abolishes the ability of CDK4 to bind to p16(INK4a). WM46 cells produce xenograft tumors when injected into immunocompromised mice.
Size	10 μg
Concentration	200 ng / μl
Applications	Purified RNA is suitable for a number of molecular biology applications including but not limited to next generation sequencing and expression library construction, PCR, real-time PCR, microarray analysis, and transfection experiements.
Other Names	Human Melanoma, patient derived tumor, tumor models, skin cancer, xenograft
Gene, Accession, CAS #	n/a
Catalog #	WM46-04-0500
Price
Order / More Info	WM46 Purified RNA from ROCKLAND IMMUNOCHEMICALS INC.
Product Specific References	Yongping Shao and Andrew E. Aplin, Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells. Cancer Res. 2010 Aug 15; 70(16): 6670-6681. doi: 10.1158/0008-5472.CAN-09-4483
產(chǎn)品資料

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