| 產(chǎn)品詳情 |
| Edit |   |
| Product Name | Recombinant Human TIM-3-Fc Chimera (carrier-free) |
| Description | TIM-3 (T cell immunoglobulin and mucin domain-3), also known as Hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein implicated in modulating innate and adaptive immune responses. TIM-3 was first discovered as a molecule expressed on IFN-γ producing CD4+T helper type 1 (Th1) and on CD8+ T cytotoxic type 1 (Tc1) cells. TIM-3 is now shown to be also expressed in Th17 cells, mast cells, macrophages, dendritic cells, monocytes, NK and NKT cells. TIM-3 negatively regulates Th1 T cell responses, but may also affect Th2-driven allergic diseases by indirectly modulating the balance between Th1 and Th2 type responses. Several genetic studies on TIM-3 polymorphisms suggest that TIM-3 is involved in susceptibility to Th2-driven allergic diseases. TIM-3 also plays a protective role in Rheumatoid arthritis. TIM-3 binding to Galectin-9 induces a range of immunosuppressive functions including Th1 cell death and a consequent decline in IFN- γ production. TIM-3 and Galectin-9 interaction leads to the enhancement of immune tolerance and the inhibition of anti-tumor immunity. Dysregulation of the TIM-3 and Galectin-9 pathway could underlie chronic autoimmune disease states, such as multiple sclerosis (MS) and TIM-3 may represent a novel target for the treatment of systemic lupus erythematosus (SLE). Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE). Tim-3 has also been shown to exist as a soluble protein. |
| Size | 25 μg |
| Concentration | n/a |
| Applications | BA |
| Other Names | Hepatitis A virus cellular receptor 2, HAVCR2, T cell immunoglobulin and mucin domain containing protein 3, CD366 |
| Gene, Accession, CAS # | Gene ID: 84868 |
| Catalog # | 759904 |
| Price | |
| Order / More Info | Recombinant Human TIM-3-Fc Chimera (carrier-free) from BIOLEGEND |
| Product Specific References | n/a |
| 產(chǎn)品資料 |
|
欧美毛片一级毛片无码免费播放,亚洲精品无码网,国产夫妻自拍在线观看
|
亚洲性爱一区,双乳被穿环调教成奴,四虎国产在线
|
JAVA无码免费专区A片,一区国产中文制服,AV网站在线免费观看
|
无码欧美成人,日本人zzzwww色视频看看,国产在线视频一区二区三区
|
四虎成人网站,先锋影音一区二区,亚洲小视频在线
|
五月丁香婷婷在线,国产精品动漫一区二区三区,国产精品1000
|
这里只有精品在线视频观看,韩国女女百合床戏无删减,欧美尤物视频
|
欧美成人三级一区二区,欧美粗又大gay69三人,小逼视频
|
肏屄视频免费在线,处女被强行糟蹋bd,A片免费的
|
欧美色操,国产性在线观看,婷婷激情综合
|
|