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產(chǎn)品名稱(chēng)

TCC, Human Antibody from HYCULT BIOTECH

產(chǎn)品貨號(hào)

HM2167F

產(chǎn)品價(jià)格

現(xiàn)貨詢(xún)價(jià)，電話(huà)：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	TCC, Human
Clone	aE11
Host Species	Mouse
Reactive Species	human, horse, pig
Isotype	IgG2a
Format	fluorescein (FITC) conjugate
Size	100 μg
Concentration	100 μg/ml
Applications	frozen sections, FC, functional studies, immunoassay, IF, paraffin sections
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Monoclonal antibody aE11 reacts with a C9 neoantigen of the terminal complement complex (TCC). The three distinct activation pathways of complement converge with the formation of a C5 convertase. The cleavage of C5 by this convertase initiates the lytic or terminal pathway. In contrast to the activation pathways, which require enzymatic cleavage for activation, the terminal pathway relies on conformational changes induced by binding. Binding of C6 facilitates binding of C7 which alters the conformation of the complex. After binding of C8, a variable number of C9 molecules associate with the C5b678 complex, which is also termed- the terminal complement complex (TCC). The formation of TCC causes lysis of cells or can trigger a variety of cellular metabolic pathways resulting in the synthesis and release of inflammatory mediators. The TCC contains neoantigens that are absent from the individual native components.- C9 neoantigens are present both in the membrane-bound (MAC) and the fluid-phase (SC5b-9) complex. TCC is present in normal human plasma and increased in patients with complement activation.
Immunogen	n/a
Other Names	Terminal complement complex, MAC complex, complement membrane attack complex, sC5b-9 complex.
Gene, Accession #	n/a
Catalog #	HM2167F
Price
Order / More Info	TCC, Human Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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