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產(chǎn)品名稱

Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) protein (His tag) from ANTIBODIES-ONLINE GmbH

產(chǎn)品貨號(hào)

ABIN805588

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

20 μg

產(chǎn)品品牌

ANTIBODIES-ONLINE GmbH

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) protein (His tag)
Description	PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. Inhibition of PPP1R14A results to increased myosin phosphorylation and enhances smooth muscle contraction in the absence of increased intracellular Ca(2+) concentration. Myosin phosphatase can reverse MYL (myosin light chain) phosphorylation to induce a state of relaxation. However, during agonist-induced contraction at constant Ca2+ concurrent inhibition of myosin phosphatase leads to increases in MYL phosphorylation and tension. These calcium-independent increases in myosin phosphorylation and tension are termed calcium sensitization.Human pregnancy is characterized by the increases of PKN1 expression and CPI-17 phosphorylation in the myometrium. PPP1R14A is mapped to chromosome 19q13.13-q13.2.PPP1R14A binds directly to protein kinase C and casein kinase I. PPP1R14A siRNA decreased the level of merlin phosphorylation and consequently Ras and ERK activity in human tumor cell lines. PKC/CPI-17 mediated pathway in histamine, triggeres cytoskeletal rearrangements causing lung microvascular barrier compromise Synonyms: Protein phosphatase 1 regulatory subunit 14A, 17 kDa PKC-potentiated inhibitory protein of PP1, CPI17, CPI-17, PPP1INL, PPP1R14A
Size	20 μg
Concentration	n/a
Applications	n/a
Other Names	MGC81874\|cpi-17\|ppp1inl\|CPI-17\|im:7147597\|ppp1r14a\|zgc:110700\|PPP1R14A\|CPI17\|PPP1INL\|Cpi17\|1110001M11Rik
Gene, Accession, CAS #	Gene ID: 94274
Catalog #	ABIN805588
Price
Order / More Info	Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) protein (His tag) from ANTIBODIES-ONLINE GmbH
Product Specific References	n/a
產(chǎn)品資料

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