| 產品詳情 |
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| Product Name | LY-2109761 |
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| Description | Purity >98% by HPLC. LY-2109761 is a highly potent and selective TGFBeta receptor type I and type II (TBetaRI/II) inhibitor with Ki of 38 nM and 300 nM respectively. It has been used to study the role of TGF-Beta signaling in tumor cell migration and metastasis in pancreatic tumor cell lines where it completely disrupts Smad-2 phosphorylation, an immediate downstream target of the kinase activity. It can also suppress radiation-induced inflammatory cytokine signaling and proangiogenic genes, including ID1, in human primary fibrobalsts. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-(2-((4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl)oxy)ethyl)morpholine |
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| Gene, Accession, CAS # | CAS: 700874-71-1 |
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| Catalog # | LS-H3632 |
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| Price | |
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| Order / More Info | LY-2109761 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 產品資料 |
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