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產(chǎn)品名稱

LY2811376 from LIFESPAN BIOSCIENCES INC.

產(chǎn)品貨號(hào)

LS-H8558

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

n/a

產(chǎn)品品牌

LIFESPAN BIOSCIENCES INC.

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	LY2811376
Description	Purity >98%. Accumulation of the Beta-amyloid (ABeta) peptide in the brain is implicated as the primary cause of neurodegeneration and progression of Alzheimer's disease. ABeta is derived from sequential proteolytic cleavage of the amyloid precursor protein (APP) by Beta-secretase (BACE) and Gamma-secretase. LY2811376 is a non-peptide inhibitor of BACE1 (IC50 = 239 nM for the synthetic peptide) that demonstrates ~10-fold selectivity over BACE2 and >50-fold selectivity over the aspartyl proteases cathepsin D, pepsin, and renin. LY2811376 treatment in APP-overexpressing cells and transgenic animal models yields a dose-dependent decrease in ABeta. Furthermore, LY2811376 has been reported to reduce C99 and sAPPBeta, the two primary APP cleavage products generated by BACE1.
Size	n/a
Concentration	n/a
Applications	n/a
Other Names	(4S)-4-[2,4-difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-4H-1,3-thiazin-2-amine
Gene, Accession, CAS #	CAS: 1194044-20-6
Catalog #	LS-H8558
Price
Order / More Info	LY2811376 from LIFESPAN BIOSCIENCES INC.
Product Specific References	n/a
產(chǎn)品資料

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