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產(chǎn)品名稱

RubR1 Activator, GF-15 from UNITED STATES BIOLOGICAL

產(chǎn)品貨號(hào)

217761

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

25mg

產(chǎn)品品牌

UNITED STATES BIOLOGICAL

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	RubR1 Activator, GF-15
Description	Purity ~98% (HPLC). A cell-permeable 2'-benzyloxy griseofulvin derivative that displays enhanced mammalian cancer-selective toxicity (IC50 ≤2, ≤4, ≤12, and ≥30uM against panels of leukemia, myeloma, solid tumors, and non-malignant cell lines, respectively), but little antifungal activity, by activating spindle-assembly-checkpoint without affecting microtubule kinetochore attachment. Cancer cells are reported to undergo multipolar (MP) mitosis with normal or supernumerary centrosomes in the presence of GF-15, resulting in subsequent apoptotic cell death. Shown to retard HT29 colon cancer & OPM2 myeloma tumor expansion in mice (20mg/kg/day i.p.) in vivo. GF-15 half-life is expected to be least 48h in cultures. Solubility: DMSO Molar Mass: 428.9
Size	25mg
Concentration	n/a
Applications	n/a
Other Names	RubR1 Activator, GF-15 (2'-Benzyloxy-2'-demethoxygriseofulvin, (2S,6'R)-(7-Chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1'-(2'-benzyloxy-6'-methylcyclohex-2'-en-4'-one), (2S,5'R)-3'-benzyloxy-7-chloro-4,6-dimethoxy-5'-methyl-spiro(benzofuran-2,4'-cyclohex-2-ene)-1',3-dione, (1'S,6'R)-2'-(benzyloxy)-7-chloro-4,6-dimethoxy-6'-methyl-3H-spiro(benzofuran-2,1'-cyclohex[2]ene)-3,4'-dione, Supernumerary Centrosomes Clustering Inhibitor)
Gene, Accession, CAS #	n/a
Catalog #	217761
Price
Order / More Info	RubR1 Activator, GF-15 from UNITED STATES BIOLOGICAL
Product Specific References	n/a
產(chǎn)品資料

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