| 產(chǎn)品詳情 |
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| Product Name | Orteronel |
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| Description | A non-steroidal inhibitor of the 17,20-lyase activity of CYP17A1 (IC50s = 48 and 19 nM for the rat and human enzyme, respectively); selective for 17,20-lyase activity over 11-hydroxylase activity and CYP3A4 (IC50s = >1,000 and >10,000 nM, respectively); decreases ACTH-induced production of DHEA, androstenedione, cortisol, and aldosterone in monkey adrenal cells (IC50s = 110, 130, 310, and 4,400 nmol/L, respectively); inhibits DHEA production in NCI-H295R human adrenocortical tumor cells; decreases DHEA, cortisol, and testosterone levels in the plasma of intact cynomolgus monkeys for at least 10 hours following a single oral dose (0.3-10 mg/kg) and continuously during chronic dosing (15 mg/kg twice daily) |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TAK-700 |
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| Gene, Accession, CAS # | CAS: 566939-85-3 |
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| Catalog # | 24191-10 |
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| Price | |
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| Order / More Info | Orteronel from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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