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產(chǎn)品名稱

Orteronel from CAYMAN CHEMICAL COMPANY

產(chǎn)品貨號

24191-25

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

25 mg

產(chǎn)品品牌

CAYMAN CHEMICAL COMPANY

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Orteronel
Description	A non-steroidal inhibitor of the 17,20-lyase activity of CYP17A1 (IC50s = 48 and 19 nM for the rat and human enzyme, respectively); selective for 17,20-lyase activity over 11-hydroxylase activity and CYP3A4 (IC50s = >1,000 and >10,000 nM, respectively); decreases ACTH-induced production of DHEA, androstenedione, cortisol, and aldosterone in monkey adrenal cells (IC50s = 110, 130, 310, and 4,400 nmol/L, respectively); inhibits DHEA production in NCI-H295R human adrenocortical tumor cells; decreases DHEA, cortisol, and testosterone levels in the plasma of intact cynomolgus monkeys for at least 10 hours following a single oral dose (0.3-10 mg/kg) and continuously during chronic dosing (15 mg/kg twice daily)
Size	25 mg
Concentration	n/a
Applications	n/a
Other Names	TAK-700
Gene, Accession, CAS #	CAS: 566939-85-3
Catalog #	24191-25
Price
Order / More Info	Orteronel from CAYMAN CHEMICAL COMPANY
Product Specific References	n/a
產(chǎn)品資料

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