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產(chǎn)品名稱

Recombinant Mouse IL-5 (carrier-free) from BIOLEGEND

產(chǎn)品貨號

581502

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

10 μg

產(chǎn)品品牌

BIOLEGEND

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Recombinant Mouse IL-5 (carrier-free)
Description	IL-5 is a homodimeric glycoprotein that was initially identified by its ability to support the in vitro growth and differentiation of mouse B cells and eosinophils. IL-5 induces eosinophil progenitor cell proliferation, terminal differentiation, and activation. In animal models of allergic diseases or helminth infection, IL-5 induces a massive proliferation of eosinophil progenitors in the bone marrow, promotes eosinophil recruitment with eotaxins, and prolongs eosinophil survival in local tissues. IL-5 regulates genes involved in the B cell terminal differentiation. IL-5 induces CD38-activated splenic B cells to differentiate into immunoglobulin M-secreting cells and go through m to g1 class switch recombination at the DNA level, resulting in immunoglobulin G1 (IgG1) production. IL-5 binds the IL-5R complex, which consists of an IL-5Rα chain specific for IL-5 and a common β-chain that is shared by the receptors for IL-3 and GM-CSF. The alpha subunit is required for ligand-specific binding whereas association with the beta subunit results in increased binding affinity. IL-5 plays important roles in the pathogenesis of asthma, hypereosinophilic syndromes, and eosinophil-dependent inflammatory disease.
Size	10 μg
Concentration	n/a
Applications	BA
Other Names	Interleukin-5, EDF, Eo-CSF, BCGF-2, BCDF-m, IgA-EF, TRF-1
Gene, Accession, CAS #	Gene ID: 16191
Catalog #	581502
Price
Order / More Info	Recombinant Mouse IL-5 (carrier-free) from BIOLEGEND
Product Specific References	n/a
產(chǎn)品資料

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