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產(chǎn)品名稱

Recombinant Mouse IL-6 (carrier-free) from BIOLEGEND

產(chǎn)品貨號(hào)

575704

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

25 μg

產(chǎn)品品牌

BIOLEGEND

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Recombinant Mouse IL-6 (carrier-free)
Description	IL-6 is a multifunctional cytokine that can regulate various immune and inflammatory responses. Several studies have suggested a crucial role for IL-6 in angiogenesis. The use of mice deficient in IL-6 (-/-) demonstrated a critical role for this protein in a mouse model of lung angiogenesis. IL-6 has been shown to cause proliferation and migration of systemic endothelial cells in culture (1). The classical responsiveness to IL-6 is governed by a receptor complex consisting of two membrane-bound subunits, an 80-kD cognate chain (IL-6R), and a ubiquitously expressed 130-kD β-chain receptor (gp130) which acts as the universal signal-transducing element for all IL-6 family cytokines (2). Alternatively, IL-6 regulation of leukocyte trafficking relies upon signaling via its soluble IL-6R (termed IL-6 trans-signaling) (3). IL-6 plays a major role in regulating neutrophil clearance during acute peritoneal inflammation; as a result of specific down-regulation of neutrophil-attracting chemokine (CXCL1/KC) production (4). IL-6 is a key factor that reciprocally regulates Th17 and Foxp3(+) Treg differentiation by inhibition of TGF-beta induced Foxp3 and induction of RORgammat, a Th17 lineage-specific transcription factor (5).
Size	25 μg
Concentration	n/a
Applications	BA
Other Names	Interleukin-6, Interferon-b2, BSF-2, CDF, HSF, HPGF
Gene, Accession, CAS #	Gene ID: 16193
Catalog #	575704
Price
Order / More Info	Recombinant Mouse IL-6 (carrier-free) from BIOLEGEND
Product Specific References	PubMed: 20530256,21321188,21771795,22219321,24944284
產(chǎn)品資料

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