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產(chǎn)品名稱

FR122047 (hydrate) from CAYMAN CHEMICAL COMPANY

產(chǎn)品貨號

10039-1

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

1 mg

產(chǎn)品品牌

CAYMAN CHEMICAL COMPANY

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	FR122047 (hydrate)
Description	FR122047 is a selective inhibitor of COX-1. The IC50 values for inhibition of human COX-1 and COX-2 are 0.028 and 65 μM, respectively.{11222} In human platelet-rich plasma, FR122047 inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation with an IC50 of 180-200 nM, which is nearly 100 times more potent than aspirin.{10791} Unlike aspirin, FR122047 does not induce gastric damage upon oral administration at doses (100 mg/kg) far in excess of the dose needed for complete suppression of platelet COX-1. In some models of inflammation, such as collagen-induced arthritis in the rat, FR122047 has an anti-inflammatory effect, implying a role for COX-1 in these models.{10672}
Size	1 mg
Concentration	n/a
Applications	n/a
Other Names	130717-51-0 FR-122047 cyclooxygenases COX-1 inhibitors hydrates hydrochlorides COX1 PGHS1 PGHS-1 prostaglandin synthases inhibition inhibits selective selectivity platelet aggregation antiinflammatory atherosclerosis
Gene, Accession, CAS #	n/a
Catalog #	10039-1
Price
Order / More Info	FR122047 (hydrate) from CAYMAN CHEMICAL COMPANY
Product Specific References	n/a
產(chǎn)品資料

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