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產(chǎn)品名稱

Recombinant Human Dual specificity protein kinase CLK2 (CLK2), partial from BIOMATIK

產(chǎn)品貨號

RPC21106

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

100ug

產(chǎn)品品牌

BIOMATIK

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Recombinant Human Dual specificity protein kinase CLK2 (CLK2), partial
Description	Purity > 85% as determined by SDS-PAGE. MW: 56.7kDa. Partial: 138-499aa. N-terminal 6xHis-B2M-tagged. Homo sapiens (Human). Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Size	100ug
Concentration	n/a
Applications	RUO
Other Names	CDC-like kinase 2
Gene, Accession, CAS #	CLK2, UniProt: P49760
Catalog #	RPC21106
Price
Order / More Info	Recombinant Human Dual specificity protein kinase CLK2 (CLK2), partial from BIOMATIK
Product Specific References	n/a
產(chǎn)品資料

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