| Description | Purity: > 90% by SDS - PAGE Format: Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 2mM DTT, 50mM NaCl, 10% glycerol. . Ataxin 3 is also known as Machado-Joseph disease protein 1. Machado-Joseph disease is one of several hereditary autosomal dominant neurodegenerative disorders. This protein contains trinucleotide CAG repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. Ataxin 3 interacts with the major histone acetyltransferases cAMP-response-element binding protein (CREB)-binding protein, p300, and p300/CREB-binding protein-associated factor and inhibits transcription by these coactivators. Also, ataxin-3 is a proteasome-associated factor that mediates the degradation of ubiquitinated proteins. Recombinant human Ataxin-3 was expressed in E.coli and purified by using conventional chromatography. |
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| Other Names | Ataxin 3, ATX3, MJD, MJD1, SCA3, ATXN3, JOS, ATXN3, AT3, EC 3.4.22., Josephin, Machado Joseph disease, Machado Joseph disease protein 1, Machado-Joseph disease protein 1 homolog, MJD gene, Rsca3, SCA3 gene, Spinocerebellar ataxia type 3 protein, |
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