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產(chǎn)品名稱

Recombinant Human Fizzy-related protein homolog (FZR1) from BIOMATIK

產(chǎn)品貨號

RPC23758

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

100ug

產(chǎn)品品牌

BIOMATIK

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Recombinant Human Fizzy-related protein homolog (FZR1)
Description	Purity > 90% as determined by SDS-PAGE. MW: 70.8kDa. Full Length of Isoform 2: 1-493aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacent of CDC20, and activates the APC/C during anaphase and telophase. The APC/C rains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate praturely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Size	100ug
Concentration	n/a
Applications	RUO
Other Names	CDC20-like protein 1Cdh1/Hct1 homolog; hCDH1
Gene, Accession, CAS #	FZR1, UniProt: Q9UM11
Catalog #	RPC23758
Price
Order / More Info	Recombinant Human Fizzy-related protein homolog (FZR1) from BIOMATIK
Product Specific References	n/a
產(chǎn)品資料

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