| Description | A selective Plk1 inhibitor (IC50s = 3 and 6 nM in an enzymatic assay and H82 lung cancer cells, respectively); over 500-fold selective over a panel of 318 kinases; inhibits tumor growth in a mouse xenograft model; increases autophagy and mTOR phosphorylation in NB4 cells; induces apoptosis in cancer cell lines |
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