| Description | A cell-permeable, reversible inhibitor of Cdk1, showing preference for Cdk1/cyclin B1 (Ki = 35 nM) over Cdk1/cyclin A (Ki = 110 nM); also inhibits Cdk2 (Ki = 340 nM), PKCδ (Ki = 318 nM), and SGK (Ki = 497 nM) but not Cdk4; reversibly arrests proliferating cells at the G2/M phase border, allowing cell synchronization |
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