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產品名稱

C5aR, Human Antibody from HYCULT BIOTECH

產品貨號

HM2094

產品價格

現貨詢價，電話：010-67529703

產品規(guī)格

100 μg

產品品牌

HYCULT BIOTECH

產品概述

產品詳情

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Antigenic Specificity	C5aR, Human
Clone	S5/1
Host Species	Mouse
Reactive Species	human, rabbit
Isotype	IgG2a
Format	unconjugated
Size	100 μg
Concentration	100 μg/ml
Applications	frozen sections, FC, functional studies, paraffin sections, WB
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	The monoclonal antibody S5/1 recognizes the human receptor for C5a (CD88). The C5a receptor- is a seven transmembrane GTP-binding-protein-coupled receptor of 45kDa which binds with high affinity to human anaphylatoxin C5a. Upon C5a binding- G-protein-dependent cellular- responses are initiated such as increased intracellular Ca2+, granule fusion with the cell membrane, enzyme release and oxidative burst suggesting that C5aR is an important mediator of inflammation. The C5a receptor is expressed on a broad range of cell types, including- neutrophils, monocytes/macrophages, dendritic cells, astrocytes and microglia. Interestingly, C5a receptor signalling has been associated with several inflammatory diseases including rheumatoid arthritis.-. Clone S5/1 was raised against a synthetic peptide comprising the N-terminal domain of the C5aR (Met1-Asn31). The antibody has been shown to inhibit the binding of C5a to its receptor.
Immunogen	Synthetic peptide comprising the N-terminal domain of the C5aR (Met1-Asn31)
Other Names	Complement component 5a receptor 1, CD88, C5aR, C5a anaphylatoxin receptor.
Gene, Accession #	n/a
Catalog #	HM2094
Price
Order / More Info	C5aR, Human Antibody from HYCULT BIOTECH
Product Specific References	n/a
產品資料

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