| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | C5/C5a, Human |
|---|
| Clone | 557 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG2a |
|---|
| Format | unconjugated |
|---|
| Size | 100 μg |
|---|
| Concentration | 100 μg/ml |
|---|
| Applications | functional studies, immunoassay, WB |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | The monoclonal antibody 557 recognizes an epitope of complement factor 5 (C5) and C5a. The complement system is composed of over 30 proteins, activated in response to tissue injury, invading pathogens or other foreign surfaces. The complement pathways can be divided in the activation pathways and lytic pathway. The activation pathways lead via C3 to the cleavage of the fifth complement component C5. C5a was first described as a cleavage product of C5 with chemotactic and anaphylatoxic properties. Further characterization revealed that C5a is an essential part of the innate immune response and evidence now suggests that it may also play a role in adaptive immunity. Complement fragment C5a is a 74 residue pro-inflammatory polypeptide. C5a induces smooth muscle contraction, increases vascular permeability, causes degranulation of mast cells and basophils, and release of lysosomal enzymes. In addition C5a stimulates the directed migration of neutrophils, eosinophils, basophils and monocytes. C5a binds to at least two seven-transmembrane domain receptors, C5aR (C5R1, CD88) and C5L2 (gpr77), expressed ubiquitously on a wide variety of cells but particularly on the surface of immune cells like macrophages, neutrophils and T cells. The former is a well-established receptor that initiates G-protein-coupled signaling via mitogen-activated protein kinase pathways, thereby by inducing synthesis of cytokines such as TNF-alpha, IL-1beta,- IL-6 and IL-8. Its in vivo blockade greatly reduces inflammatory injury. Much less is known about C5L2, occupancy of which by C5a does not initiate increased intracellular Ca(2+).The widespread expression of C5a receptors throughout the body allows C5a to elicit a broad range of effects. Thus, C5a has been found to be a significant pathogenic driver in a number of immuno-inflammatory diseases. Nowadays C5a is also implicated in non-immunological functions associated with developmental biology, CNS development and neurodegeneration, tissue regeneration, and haematopoiesis. The antibody 557 is capable to inhibit the binding of C5a to the C5a receptor through a competitive mechanism, it does not block the cleavage of C5 into C5a and C5b. |
|---|
| Immunogen | BALB/c mice were immunized with human C5 |
|---|
| Other Names | Complement C5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, CPAMD4, FLJ17816, FLJ17822, MGC142298. |
|---|
| Gene, Accession # | C5 |
|---|
| Catalog # | HM2077 |
|---|
| Price | |
|---|
| Order / More Info | C5/C5a, Human Antibody from HYCULT BIOTECH |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
外国操逼,日韩一级免费看,日韩操妣
|
日日操网,国产精品啪,久久亚洲精品国产美女写真集下载
|
精品欧美一区二区三区,啊啊啊用力艹,男女曹逼
|
一级A片高潮视频,欧美精品第三页,国产成人久久777777黄蓉
|
大香蕉大香蕉网,性猛交xxxxx乱大交孕妇,999在线视频
|
欧美日韩免费在线视频,国产69堂免费视频,亚洲AV男人天堂
|
国产一级做a爱免费视频,久久久久久a亚洲欧洲aⅴ96,成人A毛片
|
国产37页,无码人妻AⅤ一区二区三区A片一,国产精品成人AV片
|
国产精品13p,女人隐私视频黄www,成人大香蕉网站精品免费
|
99在线观看视频,成人视频网,午夜视频三区
|
|