| 產品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | TNF-RII, Human |
|---|
| Clone | 8M2 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human, rat |
|---|
| Isotype | IgG1 |
|---|
| Format | unconjugated |
|---|
| Size | 100 μg |
|---|
| Concentration | 100 μg/ml |
|---|
| Applications | FC, functional studies, immunoassay, IF, IP |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | The monoclonal antibody 80M2 recognizes the extracellular part of- membrane-bound TNF-RII as well as- the soluble form of TNF-RII which is generated by proteolytic cleavage of the extracellular domain. The soluble form can still bind TNF-alpha with high affinity and functions as a TNF-alpha antagonist.- TNF-alpha is an important signaling protein in the immune system which can activate inflammatory responses, induce apoptosis, regulate cellular proliferation, and may even promote cancer progression. TNF-alpha can bind to two structurally distinct membrane receptors, TNF-RI and TNF-RII, which have both distinct and overlapping downstream signaling cascades. TNFRI is believed to be expressed on nearly all cell types, whereas TNFRII exhibits more restricted expression, being found on certain subpopulations of immune cells and several other cell types. A dominant role of TNF-RII has been shown in thymocyte activation by TNF-alpha, whereas induction of cytotoxicity and other functions are mediated largely by TNF-RI. TNF-RI is equally well activated by both the 17 kDa soluble and 26 kDa membrane-bound form, whereas TNF-RII is activated only by the membrane bound form of TNF-alpha. The antibody is a non-agonistic receptor modulating antibody. It enhances in vitro TNF alpha responses by increasing the affinity of the soluble form of TNF-alpha for TNF-RII. |
|---|
| Immunogen | n/a |
|---|
| Other Names | Tumor necrosis factor receptor superfamily member 1B, CD120b, TNF-R2, p75, p80 TNF-alpha receptor |
|---|
| Gene, Accession # | n/a |
|---|
| Catalog # | HM2022 |
|---|
| Price | |
|---|
| Order / More Info | TNF-RII, Human Antibody from HYCULT BIOTECH |
|---|
| Product Specific References | n/a |
|---|
| 產品資料 |
|
无码熟妇人妻无码AV在线天堂,老师张开让我了一夜av,igao在线
|
色999五月色,欧美午夜AAAAAA免费视频,色77777
|
成人黄色片网站,少妇天天干,激情偷拍自拍
|
草草草影院,国产不卡精品,99热这里只有免费精品
|
在线播放成人视频,1区2区3区国产,日韩伦理在线精品毛片
|
国产伦码麻豆一二三四区,直播一级片,俺去啦欧美日韩免费久久一区二区
|
无码成人片在线观看,国产一级片免费视频,午夜亚州
|
欧美乱妇在线,微信群假人,国产乱╳╳
|
亚洲热视频,国产色婷婷精品综合在线播放,秋霞午夜伦伦A片
|
亚州AV综合色区无码一区,国产十六处破外女视频在线观看,成人毛片大全
|
|