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產(chǎn)品名稱

TNF-RII, Human Antibody from HYCULT BIOTECH

產(chǎn)品貨號

HM2023

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

50 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	TNF-RII, Human
Clone	8M2
Host Species	Mouse
Reactive Species	human, rat
Isotype	IgG1
Format	biotin conjugate
Size	50 μg
Concentration	100 μg/ml
Applications	FC, functional studies, immunoassay, IF, IP
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	The monoclonal antibody 80M2 recognizes the extracellular part of- membrane-bound TNF-RII as well as- the soluble form of TNF-RII which is generated by proteolytic cleavage of the extracellular domain. The soluble form can still bind TNF-alpha with high affinity and functions as a TNF-alpha antagonist.- TNF-alpha is an important signaling protein in the immune system which can activate inflammatory responses, induce apoptosis, regulate cellular proliferation, and may even promote cancer progression. TNF-alpha can bind to two structurally distinct membrane receptors, TNF-RI and TNF-RII, which have both distinct and overlapping downstream signaling cascades. TNFRI is believed to be expressed on nearly all cell types, whereas TNFRII exhibits more restricted expression, being found on certain subpopulations of immune cells and several other cell types. A dominant role of TNF-RII has been shown in thymocyte activation by TNF-alpha, whereas induction of cytotoxicity and other functions are mediated largely by TNF-RI. TNF-RI is equally well activated by both the 17 kDa soluble and 26 kDa membrane-bound form, whereas TNF-RII is activated only by the membrane bound form of TNF-alpha. The antibody is a non-agonistic receptor modulating antibody. It enhances in vitro TNF alpha responses by increasing the affinity of the soluble form of TNF-alpha for TNF-RII.
Immunogen	n/a
Other Names	Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor 2, CD120b, TNF-R2, p75, p80, Tumor necrosis factor receptor type II, TNF-alpha receptor.
Gene, Accession #	TNFRSF1B, TNFBR, TNFR2
Catalog #	HM2023
Price
Order / More Info	TNF-RII, Human Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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