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產(chǎn)品名稱

Apilimod mesylate from BIOVISION, INC.

產(chǎn)品貨號(hào)

B1129-25

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

25 mg

產(chǎn)品品牌

BIOVISION, INC.

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Apilimod mesylate
Description	Apilimod is a small molecule that inhibits IL-12 and IL-23 production - cytokines that are involved in autoimmune diseases through the prevention of nuclear translocation of c-Rel. It suppresses the Th1, but not the Th2, response, resulting in reduced inflammation in a mouse model of inflammatory bowel disease. Apilimod inhibits the production of IL-23p19 and IL-12/IL-23p40 subunits while decreasing skin inflammation in a clinical study of patients with psoriasis. Apilimod inhibits phosphatidylinositol-3-phosphate 5-kinase (PIKfyve; IC50 = 14 nM), which is necessary and sufficient for suppression of IL-12/IL-23p40 expression. MW: 610.7. Purity ≥98% by HPLC
Size	25 mg
Concentration	n/a
Applications	n/a
Other Names	(E)-4-(6-(2-(3-methylbenzylidene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine dimethanesulfonate
Gene, Accession, CAS #	CAS: 870087-36-8
Catalog #	B1129-25
Price
Order / More Info	Apilimod mesylate from BIOVISION, INC.
Product Specific References	n/a
產(chǎn)品資料

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