| 產(chǎn)品詳情 |
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| Antigenic Specificity | CTLA-4 |
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| Clone | A3.6B10.G1 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a, κ |
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| Format | purified |
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| Size | 50 μg |
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| Concentration | n/a |
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| Applications | ELISA Capture |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-human CD152 (CTLA-4). CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4), also known as CD152, is a protein that plays an important regulatory role in the immune system. CTLA-4 is expressed on the surface of helper T cells and transmits an inhibitory signal to T cells. Mutations in the CTLA-4 gene have been associated with various autoimmune diseases, such as systemic lupus erythematosus, insulin-dependent diabetes mellitus, and other autoimmune diseases. An identified novel transcript of the CTLA-4 gene that may represent a native soluble form of CTLA-4 (sCTLA-4) showed that eleven of twenty patients with autoimmune thyroid disease (ATD) had a high concentration of sCTLA-4, whereas only one of thirty apparently healthy volunteers contained measurable levels. sCTLA-4 immunoreactivity was inhibited by its binding to B7.1, suggesting that sCTLA-4 is a functional receptor. sCTLA-4 also plays a role in the initial immune response to infection of immune cells by HIV, along with the CD-1 pathway and others. |
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| Immunogen | Extracellular domain of human CTLA-4 and human IgG1 Fc fusion protein |
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| Other Names | Cytotoxic T-Lymphocyte Antigen 4, (CTLA4) |
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| Gene, Accession # | Gene ID: 1493 |
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| Catalog # | 525401 |
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| Price | |
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| Order / More Info | CTLA-4 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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