| 產(chǎn)品詳情 |
| Edit |   |
| Antigenic Specificity | GAD65 |
| Clone | 144 |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | IgG1 |
| Format | purified |
| Size | 100 μL |
| Concentration | n/a |
| Applications | Flow Cytometry: Assay-dependent, Immunoprecipitation: Assay-dependent, Radioimmune Assays: Assay-dependent, Western Blot: 1 μg/mL |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | GAD65 Monoclonal Antibody (144). Antibodies to glutamic acid decarboxylase-65 (GAD65) are present in autoimmune disorders such as insulin-dependent (type1) diabetes mellitus (IDDM), stiff man syndrome and polyendocrine autoimmune disease. Auto-antibodies to GAD65 are present in 60-70% of individuals with newly diagnosed IDDM and thus are important markers for disease activity. These auto-antibodies usually recognize conformation-dependent regions on GAD65 and rarely bind to the second isoform, GAD67. Auto-antibodies to GAD67 are found in only 15% of recent-onset IDDM patients and most of this binding can be blocked with GAD65, suggesting shared epitopes between the two isoforms of GAD. |
| Immunogen | n/a |
| Other Names | Glutamate decarboxylase 2; 65 kDa glutamic acid decarboxylase; Glutamate decarboxylase 65 kDa isoform; 65 kDa glutamic acid decarboxylase |
| Gene, Accession # | Entrez: 14417, 24380, 2572; Uniprot: P48320, Q05329, Q05683 |
| Catalog # | MA5-18053 |
| Price | |
| Order / More Info | GAD65 Antibody from INVITROGEN ANTIBODIES |
| Product Specific References | PubMed: 25800737 |
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