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產(chǎn)品名稱

FOXP3 Antibody from BIOLEGEND

產(chǎn)品貨號(hào)

320213

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

25 tests

產(chǎn)品品牌

BIOLEGEND

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	FOXP3
Clone	259D
Host Species	Mouse
Reactive Species	human, cross-reactivity: cynomolgus, rhesus, baboon, chimpanzee
Isotype	IgG1, κ
Format	Alexa Fluor? 647 conjugate
Size	25 tests
Concentration	n/a
Applications	Intracellular Staining for Flow Cytometry (ICFC)
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Alexa Fluor? 647 anti-human FOXP3. FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in scurfy mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. The 259D antibody recognizes human FOXP3 epitope in the region of amino acids 105-235.
Immunogen	Full-length FOXP3 protein
Other Names	Forkhead box protein P3, Scurfin, JM2, IPEX, Zinc finger protein JM2
Gene, Accession #	Gene ID: 50943
Catalog #	320213
Price
Order / More Info	FOXP3 Antibody from BIOLEGEND
Product Specific References	PubMed: 16403912,16617117,16732291,17644734,18313267,18981295,19180473,19875613,24610777,24943216,24947990
產(chǎn)品資料

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