| 產(chǎn)品詳情 |
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| Antigenic Specificity | FOXP3 |
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| Clone | 150D |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, rat, cross-reactivity: cynomolgus, rhesus, baboon |
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| Isotype | IgG1, κ |
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| Format | Alexa Fluor? 647 conjugate |
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| Size | 25 tests |
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| Concentration | n/a |
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| Applications | Intracellular Staining for Flow Cytometry (ICFC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Alexa Fluor? 647 anti-mouse/rat/human FOXP3. FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in scurfy mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. The 150D monoclonal antibody reacts with human, mouse and rat FOXP3. The 150D antibody recognizes FOXP3 epitope encoded by exon 2. |
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| Immunogen | Full-length FOXP3 protein |
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| Other Names | Forkhead box protein P3, Scurfin, JM2, IPEX, Zinc finger protein JM2 |
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| Gene, Accession # | Gene ID: 20371, 317382, 50943 |
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| Catalog # | 320013 |
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| Price | |
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| Order / More Info | FOXP3 Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 16455959,17277168,18490467,18684977,19822646,19917773,20139272,24316007,24694524,25355918 |
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